Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin.

To dose curcumin (Cur) while avoiding its degradation, a polymeric material consisting of fibers with core/shell structure was designed. Coaxial electrospinning allowed us to obtain fibers with poly(lactic acid) (PLA) core, and carboxymethylcellulose (CMC) shell. CMC/PLA fibers were compared with co...

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Bibliografiska uppgifter
Huvudupphovsmän:	León Pérez, Jadileyg Gabriela, Estrada Villegas, Gethzemani Mayeli, Morales-Corona, Juan, Olayo-Gonzalez, Roberto, Olayo-Valles, Roberto
Materialtyp:	Online
Språk:	spa
Publicerad:	Universidad Pedagógica y Tecnológica de Colombia 2020
Ämnen:	Carboximetilcelulosa, Poli(ácido láctico), Curcumina, Fibras Núcleo/Coraza, Electrohilado Coaxial. Carboxymethylcellulose, Poly (lactic acid), Curcumin, Core/Shell Fibers, Coaxial Electro-spinning.
Länkar:	https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/10864

Beskrivning
Sammanfattning:	To dose curcumin (Cur) while avoiding its degradation, a polymeric material consisting of fibers with core/shell structure was designed. Coaxial electrospinning allowed us to obtain fibers with poly(lactic acid) (PLA) core, and carboxymethylcellulose (CMC) shell. CMC/PLA fibers were compared with conventional PLA fibers. Scanning electron microscopy images allowed us to characterize the core/shell structure of CMC/PLA-Cur fibers. The presence of Cur in the fibers was confirmed by Raman spectroscopy. Thermogravimetric analysis and differential scanning calorimetry showed the effect of Cur on the thermal behavior of the fibers, and showed contrasting behavior between CMC/PLA and PLA fibers. Cur release experiments were performed at physiological pH and the results were fitted with the Korsmeyer-Peppas model. The release rate of CMC/PLA fibers was significantly lower than that of PLA fibers.