Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin.
To dose curcumin (Cur) while avoiding its degradation, a polymeric material consisting of fibers with core/shell structure was designed. Coaxial electrospinning allowed us to obtain fibers with poly(lactic acid) (PLA) core, and carboxymethylcellulose (CMC) shell. CMC/PLA fibers were compared with co...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | spa |
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Universidad Pedagógica y Tecnológica de Colombia
2020
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| Subjects: | |
| Online Access: | https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/10864 |
| _version_ | 1801706346287988736 |
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| author | León Pérez, Jadileyg Gabriela Estrada Villegas, Gethzemani Mayeli Morales-Corona, Juan Olayo-Gonzalez, Roberto Olayo-Valles, Roberto |
| author_facet | León Pérez, Jadileyg Gabriela Estrada Villegas, Gethzemani Mayeli Morales-Corona, Juan Olayo-Gonzalez, Roberto Olayo-Valles, Roberto |
| author_sort | León Pérez, Jadileyg Gabriela |
| collection | OJS |
| description | To dose curcumin (Cur) while avoiding its degradation, a polymeric material consisting of fibers with core/shell structure was designed. Coaxial electrospinning allowed us to obtain fibers with poly(lactic acid) (PLA) core, and carboxymethylcellulose (CMC) shell. CMC/PLA fibers were compared with conventional PLA fibers. Scanning electron microscopy images allowed us to characterize the core/shell structure of CMC/PLA-Cur fibers. The presence of Cur in the fibers was confirmed by Raman spectroscopy. Thermogravimetric analysis and differential scanning calorimetry showed the effect of Cur on the thermal behavior of the fibers, and showed contrasting behavior between CMC/PLA and PLA fibers. Cur release experiments were performed at physiological pH and the results were fitted with the Korsmeyer-Peppas model. The release rate of CMC/PLA fibers was significantly lower than that of PLA fibers. |
| format | Online |
| id | oai:oai.revistas.uptc.edu.co:article-10864 |
| institution | Revista Ciencia en Desarrollo |
| language | spa |
| publishDate | 2020 |
| publisher | Universidad Pedagógica y Tecnológica de Colombia |
| record_format | ojs |
| spelling | oai:oai.revistas.uptc.edu.co:article-108642022-06-15T16:57:43Z Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. Fibras núcleo/coraza de Carboximetilcelulosa/Acido Poliláctico cargadas con Curcumina. León Pérez, Jadileyg Gabriela Estrada Villegas, Gethzemani Mayeli Morales-Corona, Juan Olayo-Gonzalez, Roberto Olayo-Valles, Roberto Carboximetilcelulosa, Poli(ácido láctico), Curcumina, Fibras Núcleo/Coraza, Electrohilado Coaxial. Carboxymethylcellulose, Poly (lactic acid), Curcumin, Core/Shell Fibers, Coaxial Electro-spinning. To dose curcumin (Cur) while avoiding its degradation, a polymeric material consisting of fibers with core/shell structure was designed. Coaxial electrospinning allowed us to obtain fibers with poly(lactic acid) (PLA) core, and carboxymethylcellulose (CMC) shell. CMC/PLA fibers were compared with conventional PLA fibers. Scanning electron microscopy images allowed us to characterize the core/shell structure of CMC/PLA-Cur fibers. The presence of Cur in the fibers was confirmed by Raman spectroscopy. Thermogravimetric analysis and differential scanning calorimetry showed the effect of Cur on the thermal behavior of the fibers, and showed contrasting behavior between CMC/PLA and PLA fibers. Cur release experiments were performed at physiological pH and the results were fitted with the Korsmeyer-Peppas model. The release rate of CMC/PLA fibers was significantly lower than that of PLA fibers. Para dosificar curcumina (Cur) evitando su degradación, se diseñó un material polimérico que consta de fibras con estructura núcleo/coraza. Se utilizó la técnica de electrohilado coaxial para obtener de fibras con núcleo de ácido poliláctico (PLA) y coraza de carboximetilcelulosa (CMC). Fibras de CMC/PLA fueron comparadas con fibras convencionales de PLA cargadas con curcumina. Imágenes de microscopia electrónica de barrido permitieron caracterizar la estructura núcleo/coraza de las fibras de CMC/PLA-Cur. La presencia de Cur en las fibras fue confirmada por espectroscopía Raman. Análisis termogravimétrico y calorimetría diferencial de barrido mostraron el efecto de la incorporación de Cur en el comportamiento térmico fibras y permitió contrastar las fibras de PLA con las de CMC/PLA. Se realizaron experimentos de liberación de Cur a pH fisiológico y los resultados se ajustaron al modelo de Korsmeyer-Peppas. La tasa de liberación de fibras de CMC/PLA es significativamente menor a la de fibras de PLA sin coraza. Universidad Pedagógica y Tecnológica de Colombia 2020-06-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/10864 10.19053/01217488.v11.n2.2020.10864 Ciencia En Desarrollo; Vol. 11 No. 2 (2020): Vol 11, Núm.2 (2020): Julio-Diciembre; 141-150 Ciencia en Desarrollo; Vol. 11 Núm. 2 (2020): Vol 11, Núm.2 (2020): Julio-Diciembre; 141-150 2462-7658 0121-7488 spa https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/10864/10290 Derechos de autor 2020 CIENCIA EN DESARROLLO |
| spellingShingle | Carboximetilcelulosa, Poli(ácido láctico), Curcumina, Fibras Núcleo/Coraza, Electrohilado Coaxial. Carboxymethylcellulose, Poly (lactic acid), Curcumin, Core/Shell Fibers, Coaxial Electro-spinning. León Pérez, Jadileyg Gabriela Estrada Villegas, Gethzemani Mayeli Morales-Corona, Juan Olayo-Gonzalez, Roberto Olayo-Valles, Roberto Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. |
| title | Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. |
| title_alt | Fibras núcleo/coraza de Carboximetilcelulosa/Acido Poliláctico cargadas con Curcumina. |
| title_full | Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. |
| title_fullStr | Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. |
| title_full_unstemmed | Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. |
| title_short | Core/shell fibers of Carboxymethylcellulose/Poly(lactic acid) loaded with Curcumin. |
| title_sort | core shell fibers of carboxymethylcellulose poly lactic acid loaded with curcumin |
| topic | Carboximetilcelulosa, Poli(ácido láctico), Curcumina, Fibras Núcleo/Coraza, Electrohilado Coaxial. Carboxymethylcellulose, Poly (lactic acid), Curcumin, Core/Shell Fibers, Coaxial Electro-spinning. |
| topic_facet | Carboximetilcelulosa, Poli(ácido láctico), Curcumina, Fibras Núcleo/Coraza, Electrohilado Coaxial. Carboxymethylcellulose, Poly (lactic acid), Curcumin, Core/Shell Fibers, Coaxial Electro-spinning. |
| url | https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/10864 |
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