Cellular and genetic damage as determinants of pesticide toxicity
The use of pesticides in Colombia has allowed effective pest control, increasing agricultural, forestry and livestock productivity. However, both occupational and environmental exposure to pesticides can generate harmful effects on human health, since they can induce damage to genetic material, caus...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | spa |
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Universidad Pedagógica y Tecnológica de Colombia
2020
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| Online Access: | https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/11245 |
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| author | Valbuena, Duvan Sebastián Meléndez-Flórez, María Paula Villegas, Victoria Eugenia Sánchez, Magda Carolina Rondón-Lagos, Milena |
| author_facet | Valbuena, Duvan Sebastián Meléndez-Flórez, María Paula Villegas, Victoria Eugenia Sánchez, Magda Carolina Rondón-Lagos, Milena |
| author_sort | Valbuena, Duvan Sebastián |
| collection | OJS |
| description | The use of pesticides in Colombia has allowed effective pest control, increasing agricultural, forestry and livestock productivity. However, both occupational and environmental exposure to pesticides can generate harmful effects on human health, since they can induce damage to genetic material, causing the development of diseases, including cancer. Although the harmful effects caused by exposure to pesticides are widely known, specific information about genomic damage (gene and chromosomal damage) generated by exposure to them is scarce or absent. This review aims to describe the cellular and genetic effects induced by exposure to pesticides, as well as their implications for disease development. Considering the wide use of pesticides in
the world, as well as their impacts on health, increasing our knowledge of their harmful effects will allow us to establish future possibilities for applying tests for the early detection of diseases, as well as developing programs and/or preventive actions aimed at protecting the most vulnerable individuals in occupational and environmental settings. |
| format | Online |
| id | oai:oai.revistas.uptc.edu.co:article-11245 |
| institution | Revista Ciencia en Desarrollo |
| language | spa |
| publishDate | 2020 |
| publisher | Universidad Pedagógica y Tecnológica de Colombia |
| record_format | ojs |
| spelling | oai:oai.revistas.uptc.edu.co:article-112452022-06-15T16:57:35Z Cellular and genetic damage as determinants of pesticide toxicity Daño celular y genético como determinantes de la toxicidad de los plaguicidas Valbuena, Duvan Sebastián Meléndez-Flórez, María Paula Villegas, Victoria Eugenia Sánchez, Magda Carolina Rondón-Lagos, Milena Exposición ocupacional, Genotoxicidad, Inestabilidad cromosómica, Plaguicidas Chromosomal Instability, Genotoxicity, Occupational exposure, Pesticides The use of pesticides in Colombia has allowed effective pest control, increasing agricultural, forestry and livestock productivity. However, both occupational and environmental exposure to pesticides can generate harmful effects on human health, since they can induce damage to genetic material, causing the development of diseases, including cancer. Although the harmful effects caused by exposure to pesticides are widely known, specific information about genomic damage (gene and chromosomal damage) generated by exposure to them is scarce or absent. This review aims to describe the cellular and genetic effects induced by exposure to pesticides, as well as their implications for disease development. Considering the wide use of pesticides in the world, as well as their impacts on health, increasing our knowledge of their harmful effects will allow us to establish future possibilities for applying tests for the early detection of diseases, as well as developing programs and/or preventive actions aimed at protecting the most vulnerable individuals in occupational and environmental settings. El uso de plaguicidas en Colombia ha permitido el control efectivo de plagas, lo que se ha traducido en un aumento de la productividad agrícola, forestal y ganadera del país. A pesar de sus ventajas, la exposición ocupacional y ambiental a este tipo de compuestos tiene la capacidad de generar efectos nocivos sobre la salud humana, debido a que pueden inducir daño en el material genético y provocar enfermedades como el cáncer. Aunque los efectos nocivos de la exposición a los plaguicidas son ampliamente conocidos, la información sobre el daño genómico (génico y cromosómico) producido es escasa o ausente. Esta revisión tiene como objetivo describir los efectos celulares y genéticos inducidos por la exposición a plaguicidas, así como sus implicaciones sobre la etiología de ciertas enfermedades. Considerando el amplio uso de plaguicidas en el mundo y su impacto sobre la salud, aumentar el bagaje de conocimiento sobre sus efectos nocivos permitirá establecer posibilidades futuras de aplicación de pruebas para la detección temprana de enfermedades, así como desarrollar programas y/o acciones preventivas dirigidas a la protección de los individuos más vulnerables en entornos ocupacionales y ambientales. Universidad Pedagógica y Tecnológica de Colombia 2020-06-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/11245 10.19053/01217488.v11.n2.2020.11245 Ciencia En Desarrollo; Vol. 11 No. 2 (2020): Vol 11, Núm.2 (2020): Julio-Diciembre; 25-42 Ciencia en Desarrollo; Vol. 11 Núm. 2 (2020): Vol 11, Núm.2 (2020): Julio-Diciembre; 25-42 2462-7658 0121-7488 spa https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/11245/10295 Derechos de autor 2020 CIENCIA EN DESARROLLO |
| spellingShingle | Exposición ocupacional, Genotoxicidad, Inestabilidad cromosómica, Plaguicidas Chromosomal Instability, Genotoxicity, Occupational exposure, Pesticides Valbuena, Duvan Sebastián Meléndez-Flórez, María Paula Villegas, Victoria Eugenia Sánchez, Magda Carolina Rondón-Lagos, Milena Cellular and genetic damage as determinants of pesticide toxicity |
| title | Cellular and genetic damage as determinants of pesticide toxicity |
| title_alt | Daño celular y genético como determinantes de la toxicidad de los plaguicidas |
| title_full | Cellular and genetic damage as determinants of pesticide toxicity |
| title_fullStr | Cellular and genetic damage as determinants of pesticide toxicity |
| title_full_unstemmed | Cellular and genetic damage as determinants of pesticide toxicity |
| title_short | Cellular and genetic damage as determinants of pesticide toxicity |
| title_sort | cellular and genetic damage as determinants of pesticide toxicity |
| topic | Exposición ocupacional, Genotoxicidad, Inestabilidad cromosómica, Plaguicidas Chromosomal Instability, Genotoxicity, Occupational exposure, Pesticides |
| topic_facet | Exposición ocupacional, Genotoxicidad, Inestabilidad cromosómica, Plaguicidas Chromosomal Instability, Genotoxicity, Occupational exposure, Pesticides |
| url | https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/11245 |
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