Amaryllidaceae: Potential Source of Alkaloids. Biological and Pharmacological Activities
Plants of Amaryllidaceae family have gained importance for being used as ornamentals, for having flowers and a showy appearance, in addition to their extensive pharmacological properties. The genera mainly studied are Amaryllis, Crinum, Galanthus, Narcisus, Bruganvigia and Lycoris. They produce alka...
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| Format: | Online |
| Language: | spa |
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Universidad Pedagógica y Tecnológica de Colombia
2020
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| Online Access: | https://revistas.uptc.edu.co/index.php/ciencia_agricultura/article/view/11379 |
| _version_ | 1801706478500839424 |
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| author | Gonzalez Chavarro, Carlos Felipe Cabezas Gutiérrez, Marco Pulido Blanco, Victor Camilo Celis Ruiz, Xiomara Melissa |
| author_facet | Gonzalez Chavarro, Carlos Felipe Cabezas Gutiérrez, Marco Pulido Blanco, Victor Camilo Celis Ruiz, Xiomara Melissa |
| author_sort | Gonzalez Chavarro, Carlos Felipe |
| collection | OJS |
| description | Plants of Amaryllidaceae family have gained importance for being used as ornamentals, for having flowers and a showy appearance, in addition to their extensive pharmacological properties. The genera mainly studied are Amaryllis, Crinum, Galanthus, Narcisus, Bruganvigia and Lycoris. They produce alkaloids having as primary precursors L-phenylalanine and L-Tyrosine, which give rise to the main carbon skeleton called norbelladine, which through oxidation of the coupling of phenol, generates structures with ortho-para 'type positions, for - ortho 'and para - para', grouping the types of isoquinolic alkaloids, such as liquorine, homolicorin, crinine, haemantamine, tazetine, narcyclasin, montanin and galantamine. These alkaloids have antiviral, antimicrobial, cytotoxic, anticonvulsant, antitumor, hypotensive, and anti-inflammatory activity. The main alkaloid of this family is galantamine, being produced from the plants Leucojum sativum or Narcissus pseudonarcissus, and used therapeutically to inhibit the activity of acetylcholinesterase, counteracting the symptoms caused by the damage of the nervous system by Alzheimer's disease. |
| format | Online |
| id | oai:oai.revistas.uptc.edu.co:article-11379 |
| institution | Revista Ciencia y Agricultura |
| language | spa |
| publishDate | 2020 |
| publisher | Universidad Pedagógica y Tecnológica de Colombia |
| record_format | ojs |
| spelling | oai:oai.revistas.uptc.edu.co:article-113792021-07-13T04:46:25Z Amaryllidaceae: Potential Source of Alkaloids. Biological and Pharmacological Activities Amaryllidaceae: fuente potencial de alcaloides. Actividades biológicas y farmacológicas Gonzalez Chavarro, Carlos Felipe Cabezas Gutiérrez, Marco Pulido Blanco, Victor Camilo Celis Ruiz, Xiomara Melissa Secondary metabolism isoquinolines galantamine phytochemistry Alzheimer's disease alzheimer's disease Metabolismo secundario isoquinolicos galantamina fitoquímica alzheimer Plants of Amaryllidaceae family have gained importance for being used as ornamentals, for having flowers and a showy appearance, in addition to their extensive pharmacological properties. The genera mainly studied are Amaryllis, Crinum, Galanthus, Narcisus, Bruganvigia and Lycoris. They produce alkaloids having as primary precursors L-phenylalanine and L-Tyrosine, which give rise to the main carbon skeleton called norbelladine, which through oxidation of the coupling of phenol, generates structures with ortho-para 'type positions, for - ortho 'and para - para', grouping the types of isoquinolic alkaloids, such as liquorine, homolicorin, crinine, haemantamine, tazetine, narcyclasin, montanin and galantamine. These alkaloids have antiviral, antimicrobial, cytotoxic, anticonvulsant, antitumor, hypotensive, and anti-inflammatory activity. The main alkaloid of this family is galantamine, being produced from the plants Leucojum sativum or Narcissus pseudonarcissus, and used therapeutically to inhibit the activity of acetylcholinesterase, counteracting the symptoms caused by the damage of the nervous system by Alzheimer's disease. Las plantas de la familia Amaryllidaceae han adquirido importancia por ser utilizadas como ornamentales, por tener flores y apariencia vistosa, además de sus amplias propiedades farmacológicas. Los géneros principalmente estudiados son Amaryllis, Crinum, Galanthus, Narcisus, Bruganvigia y Lycoris. Ellos producen alcaloides teniendo como precursores primarios la L-fenilalanina y L-tirosina, los cuales dan origen al principal esqueleto carbonado denominado norbelladina, que a través de la oxidación del acoplamiento del fenol genera estructuras con posiciones de tipo orto – para´, para – orto´ y para – para´, agrupando los tipos de alcaloides isoquinólicos, tales como licorina, homolicorina, crinina, haemantamina, tazetina, narciclasina, montanina y galantamina. Estos alcaloides tienen actividad antiviral y antimicrobiana; son citotóxicos, anticonvulsivos, antitumorales, hipotensivos y antiinflamatorios. El alcaloide primordial de esta familia es la galantamina, la cual es producida a partir de las plantas Leucojum sativum o Narcissus pseudonarcissus, y utilizada terapéuticamente para inhibir la actividad de la acetilcolinesterasa, contrarrestando los síntomas de las afecciones del sistema nervioso causadas por la enfermedad de Alzheimer. Universidad Pedagógica y Tecnológica de Colombia 2020-08-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text texto application/pdf application/xml https://revistas.uptc.edu.co/index.php/ciencia_agricultura/article/view/11379 10.19053/01228420.v17.n3.2020.11379 Ciencia y Agricultura; Vol. 17 No. 3 (2020): Septiembre- Diciembre; 78-94 Ciencia y Agricultura; Vol. 17 Núm. 3 (2020): Septiembre- Diciembre; 78-94 2539-0899 spa https://revistas.uptc.edu.co/index.php/ciencia_agricultura/article/view/11379/9675 https://revistas.uptc.edu.co/index.php/ciencia_agricultura/article/view/11379/9828 Copyright (c) 2020 Carlos Felipe Gonzalez Chavarro |
| spellingShingle | Secondary metabolism isoquinolines galantamine phytochemistry Alzheimer's disease alzheimer's disease Metabolismo secundario isoquinolicos galantamina fitoquímica alzheimer Gonzalez Chavarro, Carlos Felipe Cabezas Gutiérrez, Marco Pulido Blanco, Victor Camilo Celis Ruiz, Xiomara Melissa Amaryllidaceae: Potential Source of Alkaloids. Biological and Pharmacological Activities |
| title | Amaryllidaceae: Potential Source of Alkaloids. Biological and Pharmacological Activities |
| title_alt | Amaryllidaceae: fuente potencial de alcaloides. Actividades biológicas y farmacológicas |
| title_full | Amaryllidaceae: Potential Source of Alkaloids. Biological and Pharmacological Activities |
| title_fullStr | Amaryllidaceae: Potential Source of Alkaloids. Biological and Pharmacological Activities |
| title_full_unstemmed | Amaryllidaceae: Potential Source of Alkaloids. Biological and Pharmacological Activities |
| title_short | Amaryllidaceae: Potential Source of Alkaloids. Biological and Pharmacological Activities |
| title_sort | amaryllidaceae potential source of alkaloids biological and pharmacological activities |
| topic | Secondary metabolism isoquinolines galantamine phytochemistry Alzheimer's disease alzheimer's disease Metabolismo secundario isoquinolicos galantamina fitoquímica alzheimer |
| topic_facet | Secondary metabolism isoquinolines galantamine phytochemistry Alzheimer's disease alzheimer's disease Metabolismo secundario isoquinolicos galantamina fitoquímica alzheimer |
| url | https://revistas.uptc.edu.co/index.php/ciencia_agricultura/article/view/11379 |
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