Study of novel metal complexes derived from a flexible polydentate ligand for biological and biomedical applications
This work shows the synthesis of four new lanthanide complexes of Gd(III), Eu(III), Dy(III) and Yb(III) ions, using two polydentate ligands F and L in order to evaluate their potential application on the contrast-imaging by fluorescent microscopy (MF), nuclear magnetic resonance (RMI) and as antibac...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | spa |
| Published: |
Universidad Pedagógica y Tecnológica de Colombia
2022
|
| Subjects: | |
| Online Access: | https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/14087 |
| _version_ | 1801706353336516608 |
|---|---|
| author | Londoño-Mosquera, Juan-David Polo, Dorian |
| author_facet | Londoño-Mosquera, Juan-David Polo, Dorian |
| author_sort | Londoño-Mosquera, Juan-David |
| collection | OJS |
| description | This work shows the synthesis of four new lanthanide complexes of Gd(III), Eu(III), Dy(III) and Yb(III) ions, using two polydentate ligands F and L in order to evaluate their potential application on the contrast-imaging by fluorescent microscopy (MF), nuclear magnetic resonance (RMI) and as antibacterial agents. We propose a structure where both ligands are bound to the metal centre through –OH, -N- and –COO- groups, exhibiting an apparent coordination number of 7. Moreover, r1 molar relaxivities obtained demonstrates that all the complexes had the capability to accelerate longitudinal relaxation times (T1) of water, with a r1 value of 6.45 mmol-1·L-1·s-1 for compound 1, which was higher than r1 of 2.25 mmol-1·L-1·s-1 corresponding to commercial drug Dotarem® employed for RMI. Furthermore, all quantum yields of fluorescence, in reference to fluorescein, where lower than 1%, showing a poor performance in emission processes of visible radiation. Stability constants determined as (-log[kap]) were between 21 and 18, being even better than some contrast agents. Finally, DNA binding experiments showed that all complexes had the capability to bind DNA strands by a possible intercalation mechanism. |
| format | Online |
| id | oai:oai.revistas.uptc.edu.co:article-14087 |
| institution | Revista Ciencia en Desarrollo |
| language | spa |
| publishDate | 2022 |
| publisher | Universidad Pedagógica y Tecnológica de Colombia |
| record_format | ojs |
| spelling | oai:oai.revistas.uptc.edu.co:article-140872023-06-26T20:43:15Z Study of novel metal complexes derived from a flexible polydentate ligand for biological and biomedical applications Estudio de nuevos complejos metálicos derivados de un ligando flexible polidentado para aplicaciones biológicas y biomédicas Londoño-Mosquera, Juan-David Polo, Dorian Ligando polidentado agente de contraste resonancia magnética nuclear iones lantánidos microscopía de fluorescencia Polydentate ligand, Lanthanide ions, Contrast agent, Nuclear magnetic resonance, Fluorescent microscopy This work shows the synthesis of four new lanthanide complexes of Gd(III), Eu(III), Dy(III) and Yb(III) ions, using two polydentate ligands F and L in order to evaluate their potential application on the contrast-imaging by fluorescent microscopy (MF), nuclear magnetic resonance (RMI) and as antibacterial agents. We propose a structure where both ligands are bound to the metal centre through –OH, -N- and –COO- groups, exhibiting an apparent coordination number of 7. Moreover, r1 molar relaxivities obtained demonstrates that all the complexes had the capability to accelerate longitudinal relaxation times (T1) of water, with a r1 value of 6.45 mmol-1·L-1·s-1 for compound 1, which was higher than r1 of 2.25 mmol-1·L-1·s-1 corresponding to commercial drug Dotarem® employed for RMI. Furthermore, all quantum yields of fluorescence, in reference to fluorescein, where lower than 1%, showing a poor performance in emission processes of visible radiation. Stability constants determined as (-log[kap]) were between 21 and 18, being even better than some contrast agents. Finally, DNA binding experiments showed that all complexes had the capability to bind DNA strands by a possible intercalation mechanism. El presente estudio muestra la obtención de 4 nuevos complejos lantánidos con iones Gd(III), Eu(III), Dy(III) y Yb(III), con dos ligandos polidentados F y L para evaluar su potencial aplicación en el contraste de imágenes para microscopía de fluorescencia (MF), resonancia magnética de imágenes (RMI) y como agentes antibacterianos. Se propone que los complejos poseen una estructura molecular en donde los ligandos quelan al centro metálico a través de los grupos -OH, -N- y -COO-, exhibiendo un aparente número de coordinación de 7. La relajatividad molar r1 muestra que los 4 complejos son capaces de acelerar el tiempo de relajación longitudinal T1 del agua, obteniéndose un r1 de 6.45 mmol-1·L-1·s-1 para el compuesto 1, el cual fue mayor que el valor 2.25 mmol-1·L-1·s-1 para el Dotarem® usado como medicamento de referencia en RMI. Los rendimientos cuánticos en referencia a la fluoresceína fueron menores al 1%, exhibiendo baja eficiencia en los procesos de emisión de radiación visible. Para los complejos se obtuvieron constantes de estabilidad aparente (-log[kap]) entre 21-18, siendo incluso mejores que algunos agentes de contraste. Finalmente, se confirmó que los complejos obtenidos logran unirse a las hebras del ADN a través de un posible mecanismo de intercalación. Universidad Pedagógica y Tecnológica de Colombia 2022-07-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/pdf https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/14087 10.19053/01217488.v13.n2.2022.14087 Ciencia En Desarrollo; Vol. 13 No. 2 (2022): Vol. 13 Núm. 2 (2022): Vol. 13 Núm. 2 (2022): Vol 13, Núm.2 (2022): Julio-Diciembre; 131-157 Ciencia en Desarrollo; Vol. 13 Núm. 2 (2022): Vol. 13 Núm. 2 (2022): Vol. 13 Núm. 2 (2022): Vol 13, Núm.2 (2022): Julio-Diciembre; 131-157 2462-7658 0121-7488 spa https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/14087/12652 https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/14087/12653 |
| spellingShingle | Ligando polidentado agente de contraste resonancia magnética nuclear iones lantánidos microscopía de fluorescencia Polydentate ligand, Lanthanide ions, Contrast agent, Nuclear magnetic resonance, Fluorescent microscopy Londoño-Mosquera, Juan-David Polo, Dorian Study of novel metal complexes derived from a flexible polydentate ligand for biological and biomedical applications |
| title | Study of novel metal complexes derived from a flexible polydentate ligand for biological and biomedical applications |
| title_alt | Estudio de nuevos complejos metálicos derivados de un ligando flexible polidentado para aplicaciones biológicas y biomédicas |
| title_full | Study of novel metal complexes derived from a flexible polydentate ligand for biological and biomedical applications |
| title_fullStr | Study of novel metal complexes derived from a flexible polydentate ligand for biological and biomedical applications |
| title_full_unstemmed | Study of novel metal complexes derived from a flexible polydentate ligand for biological and biomedical applications |
| title_short | Study of novel metal complexes derived from a flexible polydentate ligand for biological and biomedical applications |
| title_sort | study of novel metal complexes derived from a flexible polydentate ligand for biological and biomedical applications |
| topic | Ligando polidentado agente de contraste resonancia magnética nuclear iones lantánidos microscopía de fluorescencia Polydentate ligand, Lanthanide ions, Contrast agent, Nuclear magnetic resonance, Fluorescent microscopy |
| topic_facet | Ligando polidentado agente de contraste resonancia magnética nuclear iones lantánidos microscopía de fluorescencia Polydentate ligand, Lanthanide ions, Contrast agent, Nuclear magnetic resonance, Fluorescent microscopy |
| url | https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/14087 |
| work_keys_str_mv | AT londonomosquerajuandavid studyofnovelmetalcomplexesderivedfromaflexiblepolydentateligandforbiologicalandbiomedicalapplications AT polodorian studyofnovelmetalcomplexesderivedfromaflexiblepolydentateligandforbiologicalandbiomedicalapplications AT londonomosquerajuandavid estudiodenuevoscomplejosmetalicosderivadosdeunligandoflexiblepolidentadoparaaplicacionesbiologicasybiomedicas AT polodorian estudiodenuevoscomplejosmetalicosderivadosdeunligandoflexiblepolidentadoparaaplicacionesbiologicasybiomedicas |
