Magnetic nanoparticles of zinc and calcium for magnetic hyperthermia application
Cancer is the second cause of death in the world. Magnetic hyperthermia is an alternative treatment which consists of raising the temperature of cancer cells using magnetic nanoparticles. In this work, the synthesis and characterization of two calcium-zinc ferrites (Zn0.50Ca0.50Fe2O4 y Zn0.25Ca0.75F...
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| Format: | Online |
| Language: | spa |
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Universidad Pedagógica y Tecnológica de Colombia
2016
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| Online Access: | https://revistas.uptc.edu.co/index.php/ingenieria/article/view/4632 |
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| author | Jasso-Terán, Rosario Argentina Cortés-Hernández, Dora Alicia Sánchez-Fuentes, Héctor Javier Reyes-Rodríguez, Pamela Yajaira León-Prado, Laura Elena |
| author_facet | Jasso-Terán, Rosario Argentina Cortés-Hernández, Dora Alicia Sánchez-Fuentes, Héctor Javier Reyes-Rodríguez, Pamela Yajaira León-Prado, Laura Elena |
| author_sort | Jasso-Terán, Rosario Argentina |
| collection | OJS |
| description | Cancer is the second cause of death in the world. Magnetic hyperthermia is an alternative treatment which consists of raising the temperature of cancer cells using magnetic nanoparticles. In this work, the synthesis and characterization of two calcium-zinc ferrites (Zn0.50Ca0.50Fe2O4 y Zn0.25Ca0.75Fe2O4) are presented. These ferrites were synthesized by sol-gel method, afterwards they were calcined at 400 °C. The saturation magnetization values were 31.31 and 38.30 emu/g for Zn0.50Ca0.50Fe2O4 (ZCF050) and Zn0.25Ca0.75Fe2O4 (ZCF075, respectively. The average particle size was 14 nm for ZCF050 and 12 nm for ZCF075. Additionally, in vitro bioactivity assessment was performed by immersing samples in simulated body fluid (SBF) for 21 days under physiological conditions of pH and temperature. Only the ZCF075 ferrite showed to be bioactive. The heating capacity of ferrites was evaluated under an appropriate magnetic field using solid state magnetic induction. The working conditions were the following: A magnetic field of 10.4 KA/m and a frequency of 362 KHz. The ZCF050 ferrite reached a temperature of 41.2 °C using a concentration of ferrite/water 20 mg/2ml. The ZCF075 ferrite failed to reach 40 °C. The results obtained in the ferrite ZCF050 indicated that these nanoparticles are potential materials for cancer treatment by magnetic hyperthermia therapy. |
| format | Online |
| id | oai:oai.revistas.uptc.edu.co:article-4632 |
| institution | Revista Facultad de Ingeniería |
| language | spa |
| publishDate | 2016 |
| publisher | Universidad Pedagógica y Tecnológica de Colombia |
| record_format | ojs |
| spelling | oai:oai.revistas.uptc.edu.co:article-46322022-06-15T16:22:44Z Magnetic nanoparticles of zinc and calcium for magnetic hyperthermia application Nanopartículas magnéticas de zinc y calcio para aplicaciones en hipertermia magnética Jasso-Terán, Rosario Argentina Cortés-Hernández, Dora Alicia Sánchez-Fuentes, Héctor Javier Reyes-Rodríguez, Pamela Yajaira León-Prado, Laura Elena biomaterials magnetic hyperthermia simulated body fluid zinc and calcium ferrites biomateriales ferritas de zinc y calcio fluido fisiológico simulado hipertermia magnética Cancer is the second cause of death in the world. Magnetic hyperthermia is an alternative treatment which consists of raising the temperature of cancer cells using magnetic nanoparticles. In this work, the synthesis and characterization of two calcium-zinc ferrites (Zn0.50Ca0.50Fe2O4 y Zn0.25Ca0.75Fe2O4) are presented. These ferrites were synthesized by sol-gel method, afterwards they were calcined at 400 °C. The saturation magnetization values were 31.31 and 38.30 emu/g for Zn0.50Ca0.50Fe2O4 (ZCF050) and Zn0.25Ca0.75Fe2O4 (ZCF075, respectively. The average particle size was 14 nm for ZCF050 and 12 nm for ZCF075. Additionally, in vitro bioactivity assessment was performed by immersing samples in simulated body fluid (SBF) for 21 days under physiological conditions of pH and temperature. Only the ZCF075 ferrite showed to be bioactive. The heating capacity of ferrites was evaluated under an appropriate magnetic field using solid state magnetic induction. The working conditions were the following: A magnetic field of 10.4 KA/m and a frequency of 362 KHz. The ZCF050 ferrite reached a temperature of 41.2 °C using a concentration of ferrite/water 20 mg/2ml. The ZCF075 ferrite failed to reach 40 °C. The results obtained in the ferrite ZCF050 indicated that these nanoparticles are potential materials for cancer treatment by magnetic hyperthermia therapy. El cáncer es la segunda causa de muerte en el mundo. El tratamiento alternativo de hipertermia magnética consiste en elevar la temperatura de las células cancerígenas por medio de nanopartículas magnéticas. En este trabajo se presenta la síntesis y la caracterización de dos ferritas de zinc-calcio (Zn0.50Ca0.50Fe2O4 y Zn0.25Ca0.75Fe2O4). La síntesis de estas ferritas se llevó a cabo por el método de sol-gel, con posterior calcinación a 400 °C. La ferrita Zn0.50Ca0.50Fe2O4 (ZCF050) presentó una magnetización de 31.31 emu/g, y la ferrita Zn0.25Ca0.75Fe2O4 (ZCF075), de 38.30 emu/g. El tamaño de partícula promedio fue de 14 nm para la ZCF050 y de 12 nm para la ZCF075. Adicionalmente, se realizaron pruebas de bioactividad in vitro mediante la inmersión de muestras en un fluido fisiológico simulado por 21 días bajo condiciones fisiológicas de pH y temperatura. Se encontró que solo la ZCF075 fue bioactiva. La habilidad de calentamiento de las ferritas se evaluó utilizando un equipo de inducción magnética en estado sólido. Las condiciones de trabajo fueron las siguientes: un campo magnético de 10.2 kA/m y una frecuencia de 362 kHz. La ferrita ZCF050 alcanzó una temperatura de 41.2 °C, utilizando una concentración de ferrita/agua de 20 mg/2ml. La ferrita ZCF075 no logró alcanzar los 40 °C. Los resultados obtenidos del análisis de la ferrita ZCF050 indicaron que es un material potencial para su uso en tratamientos de cáncer por hipertermia magnética. Universidad Pedagógica y Tecnológica de Colombia 2016-05-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion investigation investigación application/pdf text/html https://revistas.uptc.edu.co/index.php/ingenieria/article/view/4632 10.19053/01211129.4632 Revista Facultad de Ingeniería; Vol. 25 No. 42 (2016); 89-98 Revista Facultad de Ingeniería; Vol. 25 Núm. 42 (2016); 89-98 2357-5328 0121-1129 spa https://revistas.uptc.edu.co/index.php/ingenieria/article/view/4632/3803 https://revistas.uptc.edu.co/index.php/ingenieria/article/view/4632/5055 |
| spellingShingle | biomaterials magnetic hyperthermia simulated body fluid zinc and calcium ferrites biomateriales ferritas de zinc y calcio fluido fisiológico simulado hipertermia magnética Jasso-Terán, Rosario Argentina Cortés-Hernández, Dora Alicia Sánchez-Fuentes, Héctor Javier Reyes-Rodríguez, Pamela Yajaira León-Prado, Laura Elena Magnetic nanoparticles of zinc and calcium for magnetic hyperthermia application |
| title | Magnetic nanoparticles of zinc and calcium for magnetic hyperthermia application |
| title_alt | Nanopartículas magnéticas de zinc y calcio para aplicaciones en hipertermia magnética |
| title_full | Magnetic nanoparticles of zinc and calcium for magnetic hyperthermia application |
| title_fullStr | Magnetic nanoparticles of zinc and calcium for magnetic hyperthermia application |
| title_full_unstemmed | Magnetic nanoparticles of zinc and calcium for magnetic hyperthermia application |
| title_short | Magnetic nanoparticles of zinc and calcium for magnetic hyperthermia application |
| title_sort | magnetic nanoparticles of zinc and calcium for magnetic hyperthermia application |
| topic | biomaterials magnetic hyperthermia simulated body fluid zinc and calcium ferrites biomateriales ferritas de zinc y calcio fluido fisiológico simulado hipertermia magnética |
| topic_facet | biomaterials magnetic hyperthermia simulated body fluid zinc and calcium ferrites biomateriales ferritas de zinc y calcio fluido fisiológico simulado hipertermia magnética |
| url | https://revistas.uptc.edu.co/index.php/ingenieria/article/view/4632 |
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