Degradation, water uptake, injectability and mechanical strength of injectable bone substitutes composed of silk fibroin and hydroxyapatite nanorods
Injectable bone substitutes are generally composite materials capable of being extruded through a device; they consist of a solid phase inside a matrix that allows the easy movement of particles. Injectable bone substitutes have the advantage of allowing its application in situ without the need of i...
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Universidad Pedagógica y Tecnológica de Colombia
2018
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| Online Access: | https://revistas.uptc.edu.co/index.php/ingenieria/article/view/8072 |
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| author | Buitrago-Vásquez, Maritza Ossa-Orozco, Claudia Patricia |
| author_facet | Buitrago-Vásquez, Maritza Ossa-Orozco, Claudia Patricia |
| author_sort | Buitrago-Vásquez, Maritza |
| collection | OJS |
| description | Injectable bone substitutes are generally composite materials capable of being extruded through a device; they consist of a solid phase inside a matrix that allows the easy movement of particles. Injectable bone substitutes have the advantage of allowing its application in situ without the need of invasive surgical techniques, guaranteeing a good recovery; for this reason, they are a promising alternative to replace conventional techniques to repair bone defects. Conventional techniques include the use of allografts and autografts, which often cause adverse reactions, and are disadvantageous for both the patient and the doctor. Furthermore, there are no reports regarding bone substitute development in Colombia, creating the necessity to research composite materials that could become injectable bone substitutes. In this study, we manufactured injectable bone substitutes with hydroxyapatite and calcium phosphate, which is most similar to bone tissue, and synthesized them in nanorods with shape and size similar to the natural hydroxyapatite found inside the body. Additionally, we used extracted silk fibroin from silkworm cocoons of Bombyx mori, a natural polymer of protein nature with high mechanical properties and excellent biocompatibility. For the materials manufactured, we evaluated degradation, in a simulated body fluid (SBF) at normal body temperature, water uptake, injectability and mechanical strength. The manufactured bone substitutes showed good degradation and water uptake properties, an approximate 97% injectability, and low mechanical resistance, indicating promising properties to be used as an injectable bone substitute. |
| format | Online |
| id | oai:oai.revistas.uptc.edu.co:article-8072 |
| institution | Revista Facultad de Ingeniería |
| language | eng |
| publishDate | 2018 |
| publisher | Universidad Pedagógica y Tecnológica de Colombia |
| record_format | ojs |
| spelling | oai:oai.revistas.uptc.edu.co:article-80722022-06-15T16:03:38Z Degradation, water uptake, injectability and mechanical strength of injectable bone substitutes composed of silk fibroin and hydroxyapatite nanorods Degradación, absorción, inyectabilidad y resistencia mecánica de sustitutos óseos inyectables compuestos de fibroína y nanobarras de hidroxiapatita Buitrago-Vásquez, Maritza Ossa-Orozco, Claudia Patricia biomaterials bone substitutes ceramics composite materials polymers biomateriales cerámicos materiales compuesto polímeros sustitutos óseos Injectable bone substitutes are generally composite materials capable of being extruded through a device; they consist of a solid phase inside a matrix that allows the easy movement of particles. Injectable bone substitutes have the advantage of allowing its application in situ without the need of invasive surgical techniques, guaranteeing a good recovery; for this reason, they are a promising alternative to replace conventional techniques to repair bone defects. Conventional techniques include the use of allografts and autografts, which often cause adverse reactions, and are disadvantageous for both the patient and the doctor. Furthermore, there are no reports regarding bone substitute development in Colombia, creating the necessity to research composite materials that could become injectable bone substitutes. In this study, we manufactured injectable bone substitutes with hydroxyapatite and calcium phosphate, which is most similar to bone tissue, and synthesized them in nanorods with shape and size similar to the natural hydroxyapatite found inside the body. Additionally, we used extracted silk fibroin from silkworm cocoons of Bombyx mori, a natural polymer of protein nature with high mechanical properties and excellent biocompatibility. For the materials manufactured, we evaluated degradation, in a simulated body fluid (SBF) at normal body temperature, water uptake, injectability and mechanical strength. The manufactured bone substitutes showed good degradation and water uptake properties, an approximate 97% injectability, and low mechanical resistance, indicating promising properties to be used as an injectable bone substitute. Los sustitutos óseos inyectables son materiales compuestos que tienen la propiedad de dejarse extruir a través de un dispositivo; constan de una fase solida inmersa en una matriz que permite el fácil movimiento del componente sólido, y tienen como ventaja permitir su aplicación in situ sin necesidad de recurrir a técnicas quirúrgicas invasivas, garantizando una buena recuperación; razón por la que son considerados una buena alternativa para reemplazar las técnicas convencionales para la reparación de defectos óseos, las cuales incluyen, principalmente, el uso de aloinjertos y autoinjertos, que generan una serie de reacciones adversas y tienen desventajas tanto para el médico como para el paciente. En Colombia no se encuentran reportes acerca del desarrollo de sustitutos óseos; esto genera la necesidad de investigar un material compuesto que tenga potencial aplicación como sustituto óseo inyectable. En la presente investigación se fabricaron sustitutos óseos de hidroxiapatita –fosfato de calcio que mayor similitud presenta con el tejido óseo–, sintetizada en nanobarras, con tamaño y forma similar a como se dispone naturalmente en el hueso; y la fibroína de seda extraída de los capullos del gusano Bombyx mori, como polímero natural de naturaleza proteica con altas propiedades mecánicas y excelente biocompatibilidad. Los materiales fabricados se caracterizaron por degradación en solución fisiológica a temperatura corporal, absorción de agua, inyectabilidad y resistencia mecánica. Los sustitutos óseos fabricados presentaron buenas propiedades de degradación y absorción, una inyectabilidad aproximada del 97 % y baja resistencia mecánica, mostrando propiedades promisorias para usarse como sustituto óseo inyectable. Universidad Pedagógica y Tecnológica de Colombia 2018-05-05 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion research investigación application/pdf application/xml https://revistas.uptc.edu.co/index.php/ingenieria/article/view/8072 10.19053/01211129.v27.n48.2018.8072 Revista Facultad de Ingeniería; Vol. 27 No. 48 (2018); 49-60 Revista Facultad de Ingeniería; Vol. 27 Núm. 48 (2018); 49-60 2357-5328 0121-1129 eng https://revistas.uptc.edu.co/index.php/ingenieria/article/view/8072/6522 https://revistas.uptc.edu.co/index.php/ingenieria/article/view/8072/7188 Copyright (c) 2018 Maritza Buitrago-Vásquez, Claudia Patricia Ossa-Orozco |
| spellingShingle | biomaterials bone substitutes ceramics composite materials polymers biomateriales cerámicos materiales compuesto polímeros sustitutos óseos Buitrago-Vásquez, Maritza Ossa-Orozco, Claudia Patricia Degradation, water uptake, injectability and mechanical strength of injectable bone substitutes composed of silk fibroin and hydroxyapatite nanorods |
| title | Degradation, water uptake, injectability and mechanical strength of injectable bone substitutes composed of silk fibroin and hydroxyapatite nanorods |
| title_alt | Degradación, absorción, inyectabilidad y resistencia mecánica de sustitutos óseos inyectables compuestos de fibroína y nanobarras de hidroxiapatita |
| title_full | Degradation, water uptake, injectability and mechanical strength of injectable bone substitutes composed of silk fibroin and hydroxyapatite nanorods |
| title_fullStr | Degradation, water uptake, injectability and mechanical strength of injectable bone substitutes composed of silk fibroin and hydroxyapatite nanorods |
| title_full_unstemmed | Degradation, water uptake, injectability and mechanical strength of injectable bone substitutes composed of silk fibroin and hydroxyapatite nanorods |
| title_short | Degradation, water uptake, injectability and mechanical strength of injectable bone substitutes composed of silk fibroin and hydroxyapatite nanorods |
| title_sort | degradation water uptake injectability and mechanical strength of injectable bone substitutes composed of silk fibroin and hydroxyapatite nanorods |
| topic | biomaterials bone substitutes ceramics composite materials polymers biomateriales cerámicos materiales compuesto polímeros sustitutos óseos |
| topic_facet | biomaterials bone substitutes ceramics composite materials polymers biomateriales cerámicos materiales compuesto polímeros sustitutos óseos |
| url | https://revistas.uptc.edu.co/index.php/ingenieria/article/view/8072 |
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