Síntesis, actividad antibacteriana e interacción del ADN con complejos de inclusión entre compuestos lantánidos y β-ciclodextrina
1 recurso en línea (páginas 99-117).
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| author | Mayor Rivera, Angélica María Aragón Muriel, Alberto Polo Cerón, Dorian |
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| description | 1 recurso en línea (páginas 99-117). |
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| spelling | repositorio.uptc.edu.co-001-23662021-02-10T19:03:15Z Síntesis, actividad antibacteriana e interacción del ADN con complejos de inclusión entre compuestos lantánidos y β-ciclodextrina Synthesis, antibacterial activity and interaction of DNA with lanthanide-β-cyclodextrin inclusion complexes Mayor Rivera, Angélica María Aragón Muriel, Alberto Polo Cerón, Dorian Actividad antibacteriana Complejos de inclusión Complejos lantánidos Interacción con ADN 1 recurso en línea (páginas 99-117). En este trabajo se han sintetizado complejos de lantánidos a partir de los cloruros de La(III), Ce(III), Sm (III) e Yb(III) con ligandos cinamato, presentando coordinación bidentada entre el grupo carboxilo del ligando y el metal lantánido. Estos compuestos se utilizaron como huéspedes de la β-ciclodextrina con el fin de obtener nuevos complejos de inclusión mediante el método de co-precipitación, utilizando N,N-dimetilformamida como disolvente. Los productos de inclusión obtenidos fueron caracterizados mediante espectroscopía IR-ATR, Raman, UV-vis, RMN 1H y 13C, DRX, TGA, DSC, análisis elemental y complexometría con EDTA. Se realizaron pruebas de actividad antibacteriana empleando 6 cepas ATTC (S. aureus ATCC 25923, S. aureus ATCC 29213, E. coli ATCC 25922, P. aeruginosa ATCC 27853, S. Typhimurium ATCC 14028 y K. pneumoniae ATCC BAA-2146) mediante el método de microdilución con caldo Mueller-Hinton; los resultados de actividad biológica para los complejos lantánidos permitieron evidenciar el efecto sinérgico entre el catión lantánido y el ligando cinamato. Igualmente, para los complejos de inclusión se observó una disminución de la concentración mínima inhibitoria (CMI) respecto a los complejos lantánidos iniciales. Los resultados obtenidos con el ADN de timo de ternera y el ADN plasmídico pBR322 permiten proponer una interacción electrostática entre los complejos evaluados y la estructura molécular del ADN. In this work, lanthanide complexes were synthesized starting from the corresponding La (III), Ce (III), Sm (III) and Yb (III) chlorides and cinnamate ligands which present bidentate coordination between the carboxyl group of the ligand and the lanthanide metal. These compounds were used as hosts of β-cyclodextrin to obtain new inclusion complexes by a co-precipitation method using N,N-dimethylformamide as solvent. The inclusion products were characterized by IR-ATR spectroscopy, Raman, UV-vis, 1H and 13C NMR,XRD, TGA-DSC, elemental analysis and EDTA complexometry. Antibacterial activity tests were performed using six ATTC strains (S. aureus ATCC 25923, S. aureus ATCC 29213, E. coli ATCC 25922, P. aeruginosa ATCC 27853, S. Typhimurium ATCC 14028 and K. pneumoniae ATCC BAA-2146) by the microdilution method with Mueller-Hinton broth. The results of the biological activity for the lanthanide complexes showed the synergistic effect between the lanthanide cation and the cinnamate ligand. For the inclusion complexes, a decrease of the minimum inhibitory concentration (MIC) was observed with respect to the initial lanthanide complexes. The results obtained with the bovine thymus DNA and the plasmid pBR322 DNA allow to propose an electrostatic interaction between the evaluated complexes and the molécular structure of the DNA. Bibliografía y webgrafía: páginas 114-117. 2019-01-31T20:39:28Z 2019-01-31T20:39:28Z 2018-07-04 Artículo de revista http://purl.org/coar/resource_type/c_6501 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Text https://purl.org/redcol/resource_type/ART http://purl.org/coar/version/c_970fb48d4fbd8a85 Mayor Rivera, A. M., Aragón Muriel, A. & Polo Cerón, D. (2018). Síntesis, actividad antibacteriana e interacción del ADN con complejos de inclusión entre compuestos lantánidos y β-ciclodextrina. Ciencia en Desarrollo, 9(2), 99-117. 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Shigekawa, “Hydrolysis of DNA and RNA by lanthanide ions: mechanistic studies leading to new applications”, Chem. Commun., vol. 16, pp. 1443–1451, 1999. https://doi.org/10.1039/ A901621J. S. Tabassum, G. Sharma, F. Arjmand, “New modulated design and synthesis of chiral CuII/SnIV bimetallic potential anticancer drug entity: In vitro DNA binding and pBR322 DNA cleavage activity”, Spectrochim. Acta Part A., vol. 90, pp. 208-217, May 2012. https://doi.org/10.1016/j. saa.2012.01.020. Ciencia en Desarrollo;Volumen 9, número 2 (Julio-Diciembre 2018) Copyright (c) 2018 Universidad Pedagógica y Tecnológica de Colombia https://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) http://purl.org/coar/access_right/c_abf2 application/pdf application/pdf Universidad Pedagógica y Tecnológica de Colombia https://revistas.uptc.edu.co/index.php/ciencia_en_desarrollo/article/view/7365/7263 |
| spellingShingle | Actividad antibacteriana Complejos de inclusión Complejos lantánidos Interacción con ADN Mayor Rivera, Angélica María Aragón Muriel, Alberto Polo Cerón, Dorian Síntesis, actividad antibacteriana e interacción del ADN con complejos de inclusión entre compuestos lantánidos y β-ciclodextrina |
| title | Síntesis, actividad antibacteriana e interacción del ADN con complejos de inclusión entre compuestos lantánidos y β-ciclodextrina |
| title_full | Síntesis, actividad antibacteriana e interacción del ADN con complejos de inclusión entre compuestos lantánidos y β-ciclodextrina |
| title_fullStr | Síntesis, actividad antibacteriana e interacción del ADN con complejos de inclusión entre compuestos lantánidos y β-ciclodextrina |
| title_full_unstemmed | Síntesis, actividad antibacteriana e interacción del ADN con complejos de inclusión entre compuestos lantánidos y β-ciclodextrina |
| title_short | Síntesis, actividad antibacteriana e interacción del ADN con complejos de inclusión entre compuestos lantánidos y β-ciclodextrina |
| title_sort | sintesis actividad antibacteriana e interaccion del adn con complejos de inclusion entre compuestos lantanidos y β ciclodextrina |
| topic | Actividad antibacteriana Complejos de inclusión Complejos lantánidos Interacción con ADN |
| url | http://repositorio.uptc.edu.co/handle/001/2366 |
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